Just pulled this off of AlinBoard. Seems to be thinking along the same lines. Not sure whom the original author is, as the poster lifted it off another board without due credit.
Beating the cardiovascular impact of tren
Long read, not my personal experience, but lifted off another forum, thought it might be of interest to others around here.
Hello everyone!
Anyone who has taken tren before knows that it fucks with your cardiovascular system.
Inject or nick a vein? Hope you enjoy dying for the next couple of minutes.
Distance running? Forget it.
Sprints? You're a funny guy.
Sex? Fuck it, I'm on bottom.
Now what if I told you, the reason tren does this, is because tren triggers an asthma like response in the body?
What the fuck, you're crazy! Tren doesn't cause asthma.
There are two main theories behind tren's cardio issues.
Pulmonary oil microembolism, where some oil is making it's way to the lungs. This possibly answers for the "tren cough" when you inject or nick a vein.
Leukotrienes are a major contributing factor of asthma.
Tren causes rises in prostaglandins. Prostaglandins are still sort of a mystery in terms of formation and role in the human body. They are made by two different pathways, cyclooxygenase and lipoxygenase. Cyclooxygenase and lipoxygenase pathways, compete to form prostaglandins; as well as thromboxanes, AKA leukotriene. Thromboxanes cause constriction of vascular smooth muscle and platelet aggregation. Leukotrienes are made in leukocytes and macrophages via the lipoxygenase pathway.
They are potent constrictors of the bronchial airways. They are also important in inflammation and hypersensitivity reaction. Because tren increases production of prostaglandins, the corresponding rise in leukotrienes causes inflammation in the lungs. This is why tren causes cardio effects such as wheezing, shortness of breath, and the in-famous "tren cough". This is the actual reason.
I originally began looking into this because I'm primarily a powerlifter, but also participate in dragon boat and enjoy dabbling in gymnastics. I've found that a leukotriene modifier, like Singulair (Montelukast), a common allergy medication, blocks leukotriene receptors in your lungs. After researching different interactions and sides for it, I deemed it safe and ordered a couple packs of it.
How did you do the experiment?
My initial testing method was I would do 3x 300m sprints using a Concept 2 rower/ERG twice a week. I would then average my times and use that as the score for the day, coming out with two scores per week. Here are the numbers:
Week before injections:
D1 - 41 seconds
D2 - 42 seconds
350mg/week:
D1 - 41 seconds
D2 - 41 seconds
575mg/week:
D1 - 40 seconds
D2 - 39 seconds
700mg/week:
D1 - 37 seconds
D2 - Untested (After seeing the trend, I didn't bother.)
As you can see, I actually IMPROVED my cardio on tren. I've found that dosing Singulair/Montelukast 10mg/ED (standard adult dose) is enough to keep any cardio impact at bay. I'm able to climb more than two flights of stairs, run with dogs (boarder collie, they run forever), and fuck forever. I've yet to notice any sides from it or any possible negative interaction with anything else I'm taking.
But what about tren cough?
It's not a problem with this. A couple weeks ago I believe I nicked or injected through a vein. Immediately post injection I saw bright red start flowing out of the injection site, not the slow trickle, but a decent flow. I felt my throat tighten and it started to feel uncomfortable, but no cough. After a couple minutes the feeling subsided and all discomfort went away.
Closing thoughts:
I'm sure Singulair isn't the only thing out there, any kind of inhale-able corticosteroid or bronchodilator could work in this situation. Anecdotal evidence supports the use of an asthma inhaler as a reactive measure to tren cough, which would also go to support the leukotriene theory. I'm sure my experiment could have been designed better, but I just went with simplicity as the biggest question to me was "Will this even work?"
Long read, but generally decent info. Would a medication like Nasacort be effective for combating the cardio affect of Tren? It says it modulates prostaglandins, and I really don't feel like going to my doctor to get a prescription like Singulair.