Bloodwork.and quality of life comes to my mind.where is the line ya know.iv been on trt for 8 years im only 38.this is due to staring aas at age 16.i know stupid.but none the less i did it.so trt is my own doing.this being said i tried to recover and my test # didnt budge.i gave it 2 years natty and felt like shit.so im on trt for life, and still find it tempting to do a higher dose and other compounds.every time i do i feel like shit.so point being i think it could have effects on the heart or whole cardio system, but it a risk to benefit factor to me.so from now on for me trt and low dose winni or gh.its about quality of life.find the sweet spot and stick too it.