Lukifer makes a good point, its really dependent on what oral you are using. But I would be more concerned about diet, protein intake and whether or not you are busting your ass in the gym then an hour or two here or there.
But just google each oral, and determine a concensus on dosage and frequency.
Something very importat you should do is look up the profile of the oral you are taking. see what the active life is. for example TBol has an active live of 16 hours.If you sleep 8 hours take half upon waking and the other half 8 hours later.
Usually 1/2 early 1/2 late. Don't really play with orals much nowadays. I will mention I never really noticed much if any difference with single or split dosing. Probably notice it less if
there are multiple compounds in the mix . I guess to optimize things at least a am pm split would be best . Can't hurt to divide things up further if you have the time and patience.
Thanks, T