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ADVERSE REACTIONS
CNS symptoms are the most frequent side effects of lidocaine administration. A rapid bolus can induce seizures. With more gradual attainment of excessive levels, drowsiness, dysarthria, dysesthesia, and even coma may occur. Lidocaine can depress cardiac function, leading to decreased lidocaine clearance, and produce an even greater increase in lidocaine concentrations. Sinus node dysfunction can also occur.