Clen does not burn fat. It raises you heart rate, makes you hotter and helps with breathing. This is good when a good diet and cardio program are in order. So to answer your question, no. It does not depend on the dose. You have to ramp up on clen because your body becomes somewhat immune to it as the days pass. This is the reason people only use it for three weeks on and three weeks off. Anything longer than that and the dose youd haveto take to feel it would be dangerous.